cordyceps sinensis mycelium powder, material, >80 mesh

1.cordyceps sinensis mycelium powder 2.powder 100% pass 80 mesh 3.from CS-4 4.polysaccharides,mannitol 5.GMP,QS

Cordycepssinensis (CS) mycelium stimulates steroidogenesis in MA-10 mouse Leydig tumor cells, but the mechanisms remain unclear. In this study, MA-10 cells were treated with different reagents in the presence or absence of CS (10 mg/ml) for 3 h to determine the mechanisms. Results illustrated that CS activated the Gsα protein subunit, but not Giα, to induce cell steroidogenesis. Moreover, PKA inhibitors inhibited 37% of CS-stimulated steroidogenesis, which demonstrated that CS might enhance the cAMP-PKA pathway to affect MA-10 cell steroidogenesis. Because of incomplete inhibition by PKA inhibitors, we also examined the PKC pathway. PKC inhibitor, phospholipase C inhibitor, and calmodulin antagonist blocked 35–52% of CS-stimulated steroidogenesis in MA-10 cells, strongly suggesting that CS had activated the PKC pathway. Co-treatment with PKA and PKC inhibitors abolished 61% of CS-stimulated steroid production, indicating that CS simultaneously activated PKA and PKC pathways. Moreover, CS induced the expression of steroidogenic acute regulatory (StAR) protein in dose- and time-dependent relationships, and PKA inhibitor, PKC inhibitor, or co-treatment with both inhibitors suppressed it. These data support that CS activates both PKA and PKC signal transduction pathways to stimulate MA-10 cell steroidogenesis.

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Item	Specification	Result	Testing Method
Assay(Mannitol)	7% Min.	10.8%	HPLC
Adenosine	0.25%/Min	0.28%	HPLC
Physical & Chemical Control
Appearance	Brown yellow Powder	Complies	Visual
Odor	Characteristic	Complies	Organoleptic
Tasted	Characteristic	Complies	Organoleptic
Sieve Analysis	100% pass 80 mesh	Complies	80mesh screen
Loss on Drying	5% Max.	3.4%	5g/100°C/2.5hrs
Ash	9% Max.	3.6%	2g/525°C/3hrs
Heavy Metal	10ppm Max	Complies	AAS
As	1ppm Max	Complies	AAS
Pb	2ppm Max	Complies	AAS
Hg	0.2ppm Max.	Complies	AAS
Pesticides Residues	1ppm Max.	Not Detected	GC
Microbiological
Total Plate Count	10000/g Max.	Complies	CP2010
Yeast & Mould	100/g Max	Complies	CP2010
Salmonella	Negative	Complies	CP2010
E.Coli	Negative	Complies	CP2010
Staphylococcus	Negative	Complies	CP2010
Conclusion	Complies with specification
Storage	In cool & dry place. Keep away from strong light and heat.
Shelf life	2 years when properly stored.
Packing	25KG/drum, Pack in paper-drums and two plastic-bags inside.